TY - JOUR A1 - Nayyar, Abhishek A1 - Kartheeki, B A1 - Sinha, Pallavi A1 - Zakaria, Kazi A1 - Chandrakant, Channe A1 - Kulkarni, Abhay T1 - Cytomorphometric analysis of exfoliated buccal mucosal cells in smokers and tobacco chewers Y1 - 2017/1/1 JF - International Journal of Histopathological Interpretation JO - Int J Histopathol Interpret SP - 1 EP - 4 VL - 6 IS - 1 UR - https://www.ijhi.org/article.asp?issn=WKMP-0130;year=2017;volume=6;issue=1;spage=1;epage=4;aulast=Nayyar DO - 10.4103/ijhi.ijhi_4_17 N2 - Aims and Objectives: Exfoliative cytology is a minimally invasive procedure that has been used for the detection of early changes in clinically normal oral mucosa of tobacco users. This study highlights the cause-effect relationship between tobacco usage in varied forms and the structural cellular and nuclear alterations in different age groups. Materials and Methods: This study was conducted with different age groups who were tobacco users as a planned, cross-sectional study. Results: The results of the study revealed that the mean nuclear diameter (ND) and cytoplasmic diameter (CD) showed a statistically significant difference in the control group and in smokers and tobacco chewers. Conclusion: Increase in ND and decreased CD, as well as an altered nucleo-cytoplasmic ratio, appear to be due to chronic tobacco usage and cytomorphometric analysis can be used to detect these cellular and subcellular alterations at an early enough stage before actually a frank, morphological change can be appreciated in relation to the oral mucosa. ER -